Syllabus

<body topmargin=0 leftmargin=0 marginheight=0 marginwidth=0> <table cellpadding=0 cellspacing=0 border=0><tr> <td valign="top" colspan=2 height=90 BGCOLOR="#006699" TEXT="#080000" bgproperties="fixed" background="109285a1erlcgo.gif"> <div> <FONT SIZE="5" COLOR="#FFCC66" FACE="Arial" ><B>Human Genetics</B></FONT><B>     |     </B><A HREF="index.htm" TARGET="_top" TITLE="Human Genetics"><U><B>home</B></U></A></div> <div> <B>Syllabus</B>   |   <A HREF="id82.htm" TARGET="_top" TITLE="Journal Club Days"><U>Journal Club Days</U></A>   |   <A HREF="id27.htm" TARGET="_top" TITLE="Journal Guidelines"><U>Journal Guidelines</U></A>   |   <A HREF="id38.htm" TARGET="_top" TITLE="Journal Club Guidelines"><U>Journal Club Guidelines</U></A>   |   <A HREF="id90.htm" TARGET="_top" TITLE="Genetics Education Model Project"><U>Genetics Education Model Project</U></A>   |   <A HREF="id53.htm" TARGET="_top" TITLE="Recessive Inheritance Model"><U>Recessive Inheritance Model</U></A>   |   <A HREF="id98.htm" TARGET="_top" TITLE="figures"><U>figures</U></A>   |   <A HREF="id52.htm" TARGET="_top" TITLE="Sample Exam I"><U>Sample Exam I</U></A>   |   <A HREF="id62.htm" TARGET="_top" TITLE="Sample Exam II"><U>Sample Exam II</U></A>   |   <A HREF="id63.htm" TARGET="_top" TITLE="Sample Exam III"><U>Sample Exam III</U></A>   |   <A HREF="id78.htm" TARGET="_top" TITLE="Sample Exam IV"><U>Sample Exam IV</U></A></div> <div> </div> </td> </tr><tr> <td valign="top" width=210 BGCOLOR="#FFCC66" TEXT="#080000" background="108d2c00dkelyh.gif"> <bR> <bR> </td> <td valign="top" height=390 BGCOLOR="#FFFFFF" TEXT="#080000"> <div> <I>Syllabus</I></div> <div> INSTRUCTOR:</div> <div> Dr. Rebecca Seipelt, <FONT SIZE="2" COLOR="#0000FF" FACE="Arial" ><U>rseipelt@mtsu.edu</U></FONT> </div> <div> DSB120D, 904-8393</div> <div> DSB 133</div> <bR> <div> CLASS TIME:  </div> <div> Monday and Wednesday at 8:05-10am</div> <bR> <div> TEXTBOOK:</div> <div> Korf, B. R.  Human Genetics: A problem-based approach.  (2nd e d.) Malden, MA: Blackwell Science, 2000.</div> <bR> <div> COURSE WEB PAGE:</div> <div> http://www.mtsu.edu/~rseipelt/web4460c</div> <bR> <div> COURSE DESCRIPTION:  </div> <div> This course is designed to explore ideas in genetics with respect to humans in a learning environment that is open and discussion-oriented.  You learned the fundamental concepts in general genetics, so we will be exploring current primary literature, model building, and case studies in further detail.  Additionally, you will be learning additional genetic concepts that were not included in general genetics.  </div> <div> This class will be unlike any other you've taken.  Some strategies for success include: Let your curiosity run wild!  Ask questions of yourself, other students, and all your teachers! Be prepared for class, discussions, labs, and exams by reading and thinking!</div> <bR> <div> ATTENDANCE POLICY:  </div> <div> Attendance at all regular class meetings is strongly encouraged.  Your attendance and participation not only improve your understanding of the subject (and thus, your grade), but also help your fellow classmates by the sharing of scientific ideas and explanations.  Also, not all topics covered in class will be in the textbook.  </div> <bR> <div> <B>GRADING:</B></div> <div> Your grade will be based on exams, projects, a genetics “journal”, and preparation for/participation in discussions and journal clubs.   </div> <div> Exams:</div> <div>  - There are three exams worth 50 points each.  The third exam will be given during the final exam time slot. </div> <div> Journal:</div> <div>  - You will be keeping a human genetics journal worth 150 points.</div> <div> Journal Club:</div> <div> - A pair of undergraduate students or a single graduate student will choose and present a human genetics primary literature research paper worth 50 points.</div> <div> Projects:</div> <div> - Laboratory research project (50 points)</div> <div> - Modeling education project (50 points)</div> <div> Grading scale:</div> <div>  - The grading scale is: A >90%, B 80-89%, C 70-79%, D 60-69%, F <60%.</div> <bR> <div> PLAGIARISM POLICY</div> <div> Unless it is a group exercise, I expect that the work you turn in is yours alone.  MTSU policy <http://www.mtsu.edu/~handbook/discproc.html> states that you can receive an F for the assignment, course, or be expelled.  This Indiana University page is an excellent source for avoiding plagiarism <http://www.indiana.edu/~wts/wts/plagiarism.html>. </div> <bR> <div> DROP/WITHDRAWAL POLICIES</div> <div> The last day to drop without a grade is February 9.  The last day to drop and receive a “W” is March 2.  A student that stops coming to class and does not officially drop the course will receive an F.  </div> <bR> <div> STUDENT DISABILITY SERVICES:</div> <div> “If you have a disability that may require assistance or accommodation, or you have questions related to any accommodation for testing, note takers, readers, etc., please speak with me as soon a possible.  Students may also contact the Office of Disabled Student Services [KUC 120] (898-2783) with questions about such services.”  -- taken from the Office of Disabled Student Services, 1999.</div> <bR> <div> TENTATIVE SCHEDULE: <FONT SIZE="2" COLOR="#BF0000" FACE="Arial" ><B>(revision 4/13/04)</B></FONT></div> <div> <TABLE BORDER="2" CELLPADDING="1" CELLSPACING="1" WIDTH="587" BORDERCOLORLIGHT="#C0C0C0" BORDERCOLORDARK="#808080" FRAME="BOX" RULES="ALL" ALIGN="BOTTOM" HSPACE="0" VSPACE="0" > <tR> <tD VALIGN=TOP HEIGHT= 16 WIDTH="65"><div> Date</div> </tD> <tD VALIGN=TOP WIDTH="454"><div> Topic</div> </tD> <tD VALIGN=TOP WIDTH="48"><div> Chpt</div> </tD> </tR> <tR> <tD VALIGN=TOP HEIGHT= 16 WIDTH="65"><div> 1/12</div> </tD> <tD VALIGN=TOP><NOBR><div> Introductions, problem-based learning, team building exercise</div> </NOBR></tD> <tD VALIGN=TOP WIDTH="48"><IMG BORDER="0" SRC="1x1.gif" HEIGHT="16" ALIGN="bottom" WIDTH="48" HSPACE="0" VSPACE="0"></tD> </tR> <tR> <tD VALIGN=TOP HEIGHT= 16 WIDTH="65"><div> 1/14</div> </tD> <tD VALIGN=TOP WIDTH="454"><div> Inborn errors I, Exercise in primary literature</div> </tD> <tD VALIGN=TOP WIDTH="48"><div> 1</div> </tD> </tR> <tR> <tD VALIGN=TOP HEIGHT= 16 WIDTH="65"><div> 1/19</div> </tD> <tD VALIGN=TOP WIDTH="454"><div> Martin Luther King Day, no class</div> </tD> <tD VALIGN=TOP WIDTH="48"><IMG BORDER="0" SRC="1x1.gif" HEIGHT="16" ALIGN="bottom" WIDTH="48" HSPACE="0" VSPACE="0"></tD> </tR> <tR> <tD VALIGN=TOP HEIGHT= 16 WIDTH="65"><div> 1/21</div> </tD> <tD VALIGN=TOP WIDTH="454"><div> Chromosome 8 lab part 1, JC 1</div> </tD> <tD VALIGN=TOP WIDTH="48"><IMG BORDER="0" SRC="1x1.gif" HEIGHT="16" ALIGN="bottom" WIDTH="48" HSPACE="0" VSPACE="0"></tD> </tR> <tR> <tD VALIGN=TOP HEIGHT= 16 WIDTH="65"><div> 1/26</div> </tD> <tD VALIGN=TOP WIDTH="454"><div> Inborn errors II, Recessive inheritance model lab</div> </tD> <tD VALIGN=TOP WIDTH="48"><div> 1</div> </tD> </tR> <tR> <tD VALIGN=TOP HEIGHT= 16 WIDTH="65"><div> 1/28</div> </tD> <tD VALIGN=TOP WIDTH="454"><div> Projects Introduction, JC 2</div> </tD> <tD VALIGN=TOP WIDTH="48"><IMG BORDER="0" SRC="1x1.gif" HEIGHT="16" ALIGN="bottom" WIDTH="48" HSPACE="0" VSPACE="0"></tD> </tR> <tR> <tD VALIGN=TOP HEIGHT= 16 WIDTH="65"><div> 2/2</div> </tD> <tD VALIGN=TOP WIDTH="454"><div> Chromosome 8 lab part 2</div> </tD> <tD VALIGN=TOP WIDTH="48"><IMG BORDER="0" SRC="1x1.gif" HEIGHT="16" ALIGN="bottom" WIDTH="48" HSPACE="0" VSPACE="0"></tD> </tR> <tR> <tD VALIGN=TOP HEIGHT= 16 WIDTH="65"><div> 2/4</div> </tD> <tD VALIGN=TOP WIDTH="454"><div> Structural genes I, JC 3</div> </tD> <tD VALIGN=TOP WIDTH="48"><div> 2</div> </tD> </tR> <tR> <tD VALIGN=TOP HEIGHT= 16 WIDTH="65"><div> 2/9</div> </tD> <tD VALIGN=TOP WIDTH="454"><div> Dominant Inheritance Model Lab, Structural genes II</div> </tD> <tD VALIGN=TOP WIDTH="48"><div> 2</div> </tD> </tR> <tR> <tD VALIGN=TOP HEIGHT= 16 WIDTH="65"><div> 2/11</div> </tD> <tD VALIGN=TOP WIDTH="454"><div> Test 1, JC 4</div> </tD> <tD VALIGN=TOP WIDTH="48"><IMG BORDER="0" SRC="1x1.gif" HEIGHT="16" ALIGN="bottom" WIDTH="48" HSPACE="0" VSPACE="0"></tD> </tR> <tR> <tD VALIGN=TOP HEIGHT= 16 WIDTH="65"><div> 2/16</div> </tD> <tD VALIGN=TOP WIDTH="454"><div> Computational Genetics Lab, ED</div> </tD> <tD VALIGN=TOP WIDTH="48"><IMG BORDER="0" SRC="1x1.gif" HEIGHT="16" ALIGN="bottom" WIDTH="48" HSPACE="0" VSPACE="0"></tD> </tR> <tR> <tD VALIGN=TOP HEIGHT= 16 WIDTH="65"><div> 2/18</div> </tD> <tD VALIGN=TOP WIDTH="454"><div> Human genome I, JC 5</div> </tD> <tD VALIGN=TOP WIDTH="48"><div> 3</div> </tD> </tR> <tR> <tD VALIGN=TOP HEIGHT= 16 WIDTH="65"><div> 2/23</div> </tD> <tD VALIGN=TOP><NOBR><div> Human genome II, Class discussion of primer and vector selection</div> </NOBR></tD> <tD VALIGN=TOP WIDTH="48"><div> 3</div> </tD> </tR> <tR> <tD VALIGN=TOP HEIGHT= 16 WIDTH="65"><div> 2/25</div> </tD> <tD VALIGN=TOP WIDTH="454"><div> X-linked I, JC 6</div> </tD> <tD VALIGN=TOP WIDTH="48"><div> 4</div> </tD> </tR> <tR> <tD VALIGN=TOP HEIGHT= 16 WIDTH="65"><div> 3/1</div> </tD> <tD VALIGN=TOP WIDTH="454"><div> Gene-specific Gradient PCR, X-linked II, ED</div> </tD> <tD VALIGN=TOP WIDTH="48"><div> 4</div> </tD> </tR> <tR> <tD VALIGN=TOP HEIGHT= 16 WIDTH="65"><div> 3/3</div> </tD> <tD VALIGN=TOP WIDTH="454"><div> Electrophoresis, JC 7</div> </tD> <tD VALIGN=TOP WIDTH="48"><IMG BORDER="0" SRC="1x1.gif" HEIGHT="16" ALIGN="bottom" WIDTH="48" HSPACE="0" VSPACE="0"></tD> </tR> <tR> <tD VALIGN=TOP HEIGHT= 16 WIDTH="65"><div> 3/8</div> </tD> <tD VALIGN=TOP WIDTH="454"><div> Ligation, Transformation</div> </tD> <tD VALIGN=TOP WIDTH="48"><IMG BORDER="0" SRC="1x1.gif" HEIGHT="16" ALIGN="bottom" WIDTH="48" HSPACE="0" VSPACE="0"></tD> </tR> <tR> <tD VALIGN=TOP HEIGHT= 16 WIDTH="65"><div> 3/10</div> </tD> <tD VALIGN=TOP WIDTH="454"><div> Chromosomes I, JC 8</div> </tD> <tD VALIGN=TOP WIDTH="48"><div> 5</div> </tD> </tR> <tR> <tD VALIGN=TOP HEIGHT= 16 WIDTH="65"><div> 3/15</div> </tD> <tD VALIGN=TOP WIDTH="454"><div> PCR on colonies, Chromosomes II, ED</div> </tD> <tD VALIGN=TOP WIDTH="48"><div> 5</div> </tD> </tR> <tR> <tD VALIGN=TOP HEIGHT= 16 WIDTH="65"><div> 3/17</div> </tD> <tD VALIGN=TOP WIDTH="454"><div> Electrophoresis, JC 9</div> </tD> <tD VALIGN=TOP WIDTH="48"><IMG BORDER="0" SRC="1x1.gif" HEIGHT="16" ALIGN="bottom" WIDTH="48" HSPACE="0" VSPACE="0"></tD> </tR> <tR> <tD VALIGN=TOP HEIGHT= 16 WIDTH="65"><div> 3/22-24</div> </tD> <tD VALIGN=TOP WIDTH="454"><div> Spring Break, no class</div> </tD> <tD VALIGN=TOP WIDTH="48"><IMG BORDER="0" SRC="1x1.gif" HEIGHT="16" ALIGN="bottom" WIDTH="48" HSPACE="0" VSPACE="0"></tD> </tR> <tR> <tD VALIGN=TOP HEIGHT= 16 WIDTH="65"><div> 3/29</div> </tD> <tD VALIGN=TOP WIDTH="454"><div> Test 2, Multifactorial I</div> </tD> <tD VALIGN=TOP WIDTH="48"><div> 6</div> </tD> </tR> <tR> <tD VALIGN=TOP HEIGHT= 16 WIDTH="65"><div> 3/31</div> </tD> <tD VALIGN=TOP WIDTH="454"><div> Multifactorial II, JC 10</div> </tD> <tD VALIGN=TOP WIDTH="48"><div> 6</div> </tD> </tR> <tR> <tD VALIGN=TOP HEIGHT= 16 WIDTH="65"><div> 4/5</div> </tD> <tD VALIGN=TOP WIDTH="454"><div> Mitochondrial I, Mitochondrial Model Lab</div> </tD> <tD VALIGN=TOP WIDTH="48"><div> 7</div> </tD> </tR> <tR> <tD VALIGN=TOP HEIGHT= 16 WIDTH="65"><div> 4/7</div> </tD> <tD VALIGN=TOP WIDTH="454"><div> Multifactorial inheritance I, JC 11 <A NAME="revision"><IMG BORDER="0" SRC="1x1.gif" HEIGHT="1" ALIGN="bottom" WIDTH="1" HSPACE="0" VSPACE="0" ></A></div> </tD> <tD VALIGN=TOP WIDTH="48"><div> 6</div> </tD> </tR> <tR> <tD VALIGN=TOP HEIGHT= 16 WIDTH="65"><div> 4/12</div> </tD> <tD VALIGN=TOP WIDTH="454"><div> Mulitfactorial inheritance II, PCR on colonies</div> </tD> <tD VALIGN=TOP WIDTH="48"><div> 6</div> </tD> </tR> <tR> <tD VALIGN=TOP HEIGHT= 16 WIDTH="65"><div> 4/14</div> </tD> <tD VALIGN=TOP WIDTH="454"><div> Case 7a, JC 12</div> </tD> <tD VALIGN=TOP WIDTH="48"><div> 7</div> </tD> </tR> <tR> <tD VALIGN=TOP HEIGHT= 16 WIDTH="65"><div> 4/19</div> </tD> <tD VALIGN=TOP WIDTH="454"><div> Case 7b, electrophoresis on PCR</div> </tD> <tD VALIGN=TOP WIDTH="48"><div> 7</div> </tD> </tR> <tR> <tD VALIGN=TOP HEIGHT= 16 WIDTH="65"><div> 4/21</div> </tD> <tD VALIGN=TOP WIDTH="454"><div>  Case 8a, JC 13, ED</div> </tD> <tD VALIGN=TOP WIDTH="48"><div> 8</div> </tD> </tR> <tR> <tD VALIGN=TOP HEIGHT= 16 WIDTH="65"><div> 4/26</div> </tD> <tD VALIGN=TOP WIDTH="454"><div> Journal Club 14, Case 8b</div> </tD> <tD VALIGN=TOP WIDTH="48"><div> 8</div> </tD> </tR> <tR> <tD VALIGN=TOP HEIGHT= 16 WIDTH="65"><div> 4/28</div> </tD> <tD VALIGN=TOP WIDTH="454"><div> Journal Club 15, Education Model Presentations</div> </tD> <tD VALIGN=TOP WIDTH="48"><IMG BORDER="0" SRC="1x1.gif" HEIGHT="16" ALIGN="bottom" WIDTH="48" HSPACE="0" VSPACE="0"></tD> </tR> <tR> <tD VALIGN=TOP HEIGHT= 16 WIDTH="65"><div> 5/3</div> </tD> <tD VALIGN=TOP WIDTH="454"><div> Education Model Presentations</div> </tD> <tD VALIGN=TOP WIDTH="48"><IMG BORDER="0" SRC="1x1.gif" HEIGHT="16" ALIGN="bottom" WIDTH="48" HSPACE="0" VSPACE="0"></tD> </tR> </TABLE></div> <bR> <div> ED = Education Project Deadline</div> </td> </tr></table></body>